ZCCHC2 is a 1178 amino acid protein that contains one CCHC-type zinc finger, suggesting a role in transcriptional regulation. The gene encoding ZCCHC10 maps to human chromosome 18, which encodes over 300 genes and contains nearly 76 million bases. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic telangiectasia, and erythropoietic protoporphyria. Translocation between chromosome 18 and 14 is also the most common translocation in cancers and occurs in follicular lymphomas.